Cell Senescent is a phenomenon characterized by stopping the cell division but do not die when they should. This cell response is initially observed in cell culture. Later on, it was identified both in vitro and in vivo for cells subjected to different forms of stress such as accumulation of reactive oxygen species and/or DNA damage.
These observations led the scientist to relate cell senescence with the process of aging and chronic disease development.
Scientists at the University of California, San Francisco (UCSF), addressed that they have discovered how immune cells naturally clear the body of senescent cells.
The study was published in the journal Med in a paper titled, “Invariant natural killer T cells coordinate removal of senescent cells.”
The study showed that activated invariant natural killer T cells are able to identify and remove the senescence cells. The activated iNKT cells also substantially lower blood glucose in high-fat diet mice and reduced lung damage in drug-induced lung injury mice.
“…Taken together along with the results presented here, these considerations suggest that specific activation of surveillance responses by iNKT cells provides a rationale for developing the next generation of approaches to eliminate inflammatory senescent cells associated with chronic diseases,” concluded the scientists.
Their finding is the first evidence to note that activated iNKT cells can remove senescent cells. This new findings in mice may lead to new strategies to treat age-related chronic diseases with cellular immunotherapy.
To further understanding the role of iNKT cells, click the link below, https://www.youtube.com/watch?v=2dKpT5HM1oQ
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